Endocrine Abstracts

Background: Prostate cancer is the most commonly diagnosed male malignancy. Androgen Deprivation Therapy (ADT) with GnRH agonist is commonly used intreating localized prostate cancer. Side effect of ADT is a loss of bone density resulting inosteopenia or osteoporosis. Research concerningpossible molecular and cellular mechanisms of ADT-induced bone changes are still incomplete. Matrix Gla Protein (MGP) is a vitamin-K-dependent protein which is synthesized in a variety of tissu...

Introduction: Hyperthyroidism-associated myocardial infarction with normal epicardial coronary arteries on angiogram is seldom reported.Case report: A 61-year-old Caucasian man, resident in an iodine sufficient area, presented with chest pain in the emergency unit. ECG revealed inferolateral myocardial infarction with ST-segment elevation. Soon after admission, the patients developed collapse due to primary ventricular fibrillation, requiring defibrillat...

A 17 year old girl was referred to us from the gynaecology department with history of primary amenorrhea. She was otherwise well and previous medical history included severe acne requiring referral to ENT, plastic surgery and dermatology services at age 13 and hirsutism for which she had privately funded laser treatment. On examination she had acanthosis nigricans and BMI of 22 but was virilised with clitoromegaly, hypertrophied labia majora and hirsuitism. Pelvic ultrasound r...

Serum ALT concentrations give some insight into liver fat accumulation and relate to metabolic syndrome: values>29 IU/L double risk of type 2 diabetes independent of other risk predictors. Women with PCOS are at increased risk of diabetes and CVD whereas metformin treatment modulates the progress of metabolic syndrome. Consequently, we investigated the effects of protracted metformin treatment on circulating ALT in obese women with PCOS.Methods<p...

Background: Selenium (Se) sufficiency is beneficial for thyroid metabolism and pregnancy course due to its antioxidant and anti-inflammatory properties. As a part of selenoenzymes, it ameliorates autoimmune thyroid disease (AITD) progression in mothers and provides proper neurogenesis in fetuses. Despite lacking or conflicting recommendations for its supplementation in pregnancy, Se is used in a clinical setting, as a common constituent of multivitamin pregnancy diet supplemen...

Introduction: The GH/insulin-like growth factor 1 (IGF1) system may modulate the pituitary-gonadal axis in males. Direct pituitary and/or testicular effects might be involved, as well as indirect effects on sex hormone binding globulin (SHBG) and aromatase activity.Methods/design: Nine healthy male volunteers (mean age 37, range 29–49 years) were treated in random order with increasing doses of GH for three weeks (1st week 0.01, 2nd week 0.02, 3rd 0...

We report a 17-year-old male who presented with symptoms of absent secondary sexual characteristics, decreased appetite and infrequent non-specific abdominal pain. He had no complaints of headache, altered sense of smell or colour blindness. His other siblings had normal growth.On examination, he had normal male body habitus, height (157 cm), no gynaecomastia, axillary and beard hair (tanner stage 1) pubic hair (tanner stage 2), testes (12 ml bilaterally...

Background: Selenium (Se) is a crucial micronutrient for thyroid gland homeostasis. Acting through iodothyronine deiodinases, it regulates thyroid hormones synthesis and by glutathione peroxidases removes harmful free radicals. The Se role in pathogenesis of autoimmune thyroiditis is currently under investigation. Se supplementation decreases antithyroid antibodies during pregnancy, may prevent from postpartum thyroiditis and is approved for treatment of mild Graves’ opht...

Introduction: We have recently described a preformed signalosome associated with the GnRH receptor (GnRHR), which undergoes dynamic rearrangement upon stimulation with GnRH. This signaling complex included c-Src, focal adhesion kinase (FAK), paxillin, vinculin, tubulin, caveolin-1, protein kinase C (PKC) δ, PKCε, PKCα, Ras, kinase suppressor of Ras-1 (KSR), MAPK kinase (MEK) 1/2, ERK1/2 and the GnRHR. To sort out the role of the signalosomes associated with the ...

The association of low body weight due to excessive exercise and/or eating disorders, and hypothalamic amenorrhoea is well documented. Delayed or arrest of puberty may occur if low body weight occurs before or during puberty. Normal menstruation is restored once a healthy body weight is regained. In this case, body weight normalised but ovarian function did not.A 34-year-old woman attended our thyroid clinic for subclinical hypothyroidism following an ep...